ITA | ENG
B015930 - DRUG DISCOVERY
Main information
Teaching Language
Course Content
Learning Objectives
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2015-16
Coorte 2014 - Second Cycle Degree in MOLECULAR BIOTECHNOLOGIES
Course year
Second year - First Semester
Belonging Department
Chemistry "Ugo Schiff"
Course Type
Single education field course
Scientific Area
CHIM/06 - ORGANIC CHEMISTRY
Credits
6
Teaching Hours
52
Teaching Term
21/09/2015 ⇒ 23/12/2015
Attendance required
No
Type of Evaluation
Final Grade
Course Content
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Course program
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Lectureship
Teaching Language
Italian
Course Content
Introduction to drug discovery; introduction to QSAR;; molecular modeling; principles of conformational analysis; visualization of macromolecules; principles and applications of molecular docking; patent basics; practical cases of molecular docking
Learning Objectives
Knolewdge acquired:
Basics of Drug discovery
Competence acquired
Theoretical and practical principles for the rational design of natural product-mimetic compounds of biological interest.
Skills acquired (at the end of the course):
Design and evaluation of target-ligand interactions at molecular level
Basics of Drug discovery
Competence acquired
Theoretical and practical principles for the rational design of natural product-mimetic compounds of biological interest.
Skills acquired (at the end of the course):
Design and evaluation of target-ligand interactions at molecular level
Teaching Methods
Total hours of the course (including the time spent in attending lectures, seminars, private study, examinations, etc...): 150
Hours reserved to private study and other individual formative activities: 102
Contact hours for: Lectures (hours): 48
Contact hours for: Laboratory (hours):0
Hours reserved to private study and other individual formative activities: 102
Contact hours for: Lectures (hours): 48
Contact hours for: Laboratory (hours):0
Further information
Frequency of lectures, practice and lab:
Recommended
Teaching tools
Softwares for protein visualization and molecular docking simulations
Recommended
Teaching tools
Softwares for protein visualization and molecular docking simulations
Type of Assessment
written exam
Course program
Introduction to drug discovery; target and ligand identification; virtual screening; fragment-based drug discovery; lead transformations; isosteres and bioisosteres; introduction to QSAR; peptide synthesis and SPPS; case study: HIV drug discovery; molecular modeling; principles of conformational analysis; PDB and PubMed databases; visualization of macromolecules; principles and applications of molecular docking; patent basics; practical cases of molecular docking.